Buses carrying evacuees left Eastern Ghouta through the Harasta humanitarian corridor, footage showed on Saturday.
The Syrian Arab Army (SAA) reportedly reached a deal with militants which allow some 6,000 people, including 1,500 militants to flee.
According to the Russian Ministry of Defence, as a result of the agreement, militants of the armed group Ahrar al-Sham from the Harasta al-Basal settlement would be evacuated under the control of the Russian Reconciliation Centre for Syria.
According to the Russian Ministry of Defence, 4,120 militants and their families were evacuated from the enclave in the last two days.
Footage shows bags being loaded onto waiting coaches as military personnel and members of the Syrian Arab Red Crescent aided the process.
All evacuees will be brought to the settlement of Qalaat al-Madiq, in the Idlib de-escalation zone, the Ministry of Defence said.