The victims were in a car on the road between Qatan and Khashgha when missiles fired from a US drone hit their vehicle on Friday.
It was the third US drone strike east of Yemen in the past four days. Yemen’s defense ministry has also confirmed the attack and the death toll.
Washington has been using its assassination drones in Pakistan, Afghanistan, Yemen and Somalia and claims that it is targeting terrorists, but the attacks have mostly led to massive civilian deaths.
The UN has slammed the US drone attacks as targeted killings and says they pose a challenge to the international law.
Reports, however, say that the CIA is seeking to expand its covert drone attacks in Yemen, despite the fact that the airborne strikes mostly result in civilian casualties.