The American soldiers were killed after their vehicle was targeted with an explosive device near the village of Markadeh on Hasakah-Dayr al-Zawr road, SANA reported Sunday.
It added that a translator was among the slain soldiers.
Following the explosion, the US forces cordoned off the area amid the flight of US warplanes in the area.
The slain soldiers were taken to a US base in the Shaddadi area in the Hasakah countryside.
Other reports said the bomb attack was allegedly carried out by Daesh.
A US-led military coalition has been bombarding what it claims Daesh positions inside Syria since September 2014 without any authorization from the Damascus government or a UN mandate.
A large number of American troops are also operating on the ground in eastern and northeastern Syria. While the US claims its troops in Syria are assisting the allied SDF Kurdish militants in their purported fight against Daesh, there is ample evidence which shows the US is there to loot Syria’s oil resources.