According to state police, the truck veered off the main road at a rest stop along I-90 in northern Idaho on Friday night as the driver attempted to use the interstate on-ramp.
The 50-year-old man at the wheel lost control of the truck and accidentally drove into a hazardous materials containment area and disabled his vehicle by driving over a snowbank at the end of the hazmat area.
No one was hurt in crash but police had to completely shut down the road for four miles as a precaution, because the truck was transporting 16 missiles, each one weighing 900kg (2,000lbs).
The driver was cited for inattentive driving.
The US military has a long history of botched transportation of dangerous weapons and military equipment.
In November 2015, an astonishing video surfaced showing an armored escort vehicle colliding into a nuclear warhead loaded into a truck near Malmstrom Air Force Base in Montana.
An astonishing video has surfaced showing an armored vehicle colliding into a nuclear warhead in the United States.
The escort vehicle was speeding behind the truck but the driver failed to react in time and ended up driving into it.
More recently, in February this year, a truck hauling a shipment of US Navy-owned military munitions crashed into two commercial trucks on US Highway 212 in southeastern Montana.
The US Air Force sent a six-member disposal unit to the scene, who then used 58kg of explosives to detonate 60 hazardous munitions that were damaged. The unit recovered 420 other projectiles.
In late January, two US military vehicles crashed in New Mexico, injuring all 9 personnel onboard, two of them critically.
The US military has been blamed for similar incidents abroad, notably in Germany and Japan.