The official Syrian Arab News Agency (SANA) said the aggression took place in the early hours of Monday, which left three civilians dead.
According to the report, the Israeli missiles came from the Lebanese airspace.
Since the start of the foreign-backed war on Syria in 2011, Israel has carried out hundreds of strikes in the country, targeting government troops and their allies.
Last Monday, the Syrian air defenses intercepted a number of Israeli missiles over the ancient city of Palmyra in the central province of Homs, and downed “a number of enemy’s missiles”.
Back then, Israeli media claimed that the target site was the T4 base in Homs, a base that Israel has attacked a number of times in the past.
Israel’s aggressive moves have been viewed by observers as an attempt to weaken the Damascus government as it increasingly gains the upper hand in its fight against terrorist groups.
Syria has been gripped by foreign-backed militancy since March 2011. The Syrian government says the Israeli regime and its Western and regional allies are aiding Takfiri terrorist groups that are wreaking havoc in the country.
Syrian government forces have taken back many areas once controlled by the terrorist groups. The government and allied forces are currently busy fighting last bastions of militants in the northwestern province of Idlib and areas in the neighboring Aleppo province.