The crowd released tens of thousands of red, black and white balloons with the message to the president, “Leave, Ali,” painted on them.
The near-daily protests in Yemen have been going on for nearly three months but Saleh, who has been in power for 32 years, has refused to leave.
Friday’s protest is dubbed “Day of Gratitude to the South,” honoring southerners 2007 uprising against Saleh.
Meanwhile, tens of thousands of Saleh’s supporters are rallying outside the presidential palace in Sanaa.
Saleh has spurned mediation efforts by Persian Gulf countries that would have had him step down in return for immunity.