Witnesses say dozens from both sides, including police, were injured after thousands of members of the Bani Hassan tribe clashed with around 300 anti-government demonstrators demanding reforms in Mafraq on Friday.
Several shops were also destroyed during the clashes, AFP reported.
The demonstrators have reportedly sought refuge in a mosque and according to witnesses the situation is still tense in the city.
Bani Hassan, one of Jordan’s largest tribes, which supports the government, on Thursday warned against holding anti-government demonstration in Mafraq.
Similar anti-government rallies were held in the capital, Amman, and several other cities following the Friday Prayers.
Jordanians have been holding street protests demanding political reform, including the election of the prime minister by popular vote, and an end to corruption since January. There have been no calls for the king to be removed.
Since the beginning of protest rallies, Jordanian ruler, King Abdullah II, has sacked two prime ministers in a bid to avoid more protests. Awn al-Khasawneh, a judge at International Court of Justice, is Jordan’s third premier this year.
The king has also amended 42 articles in the 60-year-old constitution, giving parliament a stronger role in decision-making.