The sources said that the warplanes bombed residential areas heavily in the town of al-Souseh, killing a child and wounding more women and children.
The sources further said that some of the injured are in critical conditions.
In July, the US fighter jets intensified their attacks on several regions in Southeastern Deir Ezzur, destroying infrastructures and residential areas.
The number of casualties was unknown due to the heavy bombardment.
Early reports said all members of at least two families were killed in the air attacks on al-Souseh.
The warplanes have been bombing villages, townships and towns in Deir Ezzur under the pretext of war on ISIL.