Somali tribal elders, speaking on the condition of anonymity, told Press TV that the remote-controlled aerial vehicles fired several missiles at Bilis Qooqaani town, which is located 448 kilometers (278 miles) southwest of the Somali capital Mogadishu, on Friday morning.
They added that 21 people were killed and scores of others injured in the drone attacks.
The aerial attacks followed US terror drone strikes against the same area on Thursday evening.
Witnesses told Press TV that at least 14 people were killed and 37 others injured in the strikes.
Somalia is the sixth country where the United States has used assassination drones to launch deadly missile strikes.
The US military has also used drones in Afghanistan, Pakistan, Libya, Iraq, and Yemen.
On October 28, the United States admitted to flying the terror aircraft from a base in Ethiopia.
“The US has unarmed and unmanned aircraft at a facility there (Ethiopia) to be used only for surveillance as part of a broad, sustained integrated campaign to counter terrorism,” said Pentagon spokesman Captain John Kirby.
The confirmation appeared a day after The Washington Post revealed in a report that the US flies “armed” drones from an airfield in Ethiopia’s southern city of Arba Minch.
Somalia has not had a functioning government since 1991, when warlords overthrew former dictator Mohamed Siad Barre.
Strategically located in the Horn of Africa, Somalia remains one of the countries generating the highest number of refugees and internally displaced persons in the world.